THE JAPANESE SOCIETY OF TOXICOLOGY

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Awards / Pfizer Award

Winners

2023

Title: Involvement of metal transporters in the intestinal uptake of cadmium
Author: Hisayoshi Ohta, Kenichi Ohba
J. Toxicol. Sci. Vol.45, No.9, 539-548, 2020
Title: A novel screening test to predict the developmental toxicity of drugs using human induced pluripotent stem cells
Author: Nobuo Aikawa
J. Toxicol. Sci. Vol.45, No.4, 187-199, 2020
Title: Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation
Author: Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda
J. Toxicol. Sci. Vol.45, No.4, 227-236, 2020

2022

Title: Comparison of the developmental/reproductive toxicity and hepatotoxicity of phthalate esters in rats using an open toxicity data source
Author: Kaori Ambe, Yuko Sakakibara, Aya Sakabe, Hayato Makino, Tatsuya Ochibe, Masahiro Tohkin
J. Toxicol. Sci. Vol.44, No.4, 245-255, 2019
Title: Intracellular accumulation-independent cytotoxicity of pentavalent organoantimony compounds in cultured vascular endothelial cells
Author: Takato Hara, Shihoko Nakano, Yuki Kitamura, Chika Yamamoto, Shuji Yasuike, Toshiyuki Kaji
J. Toxicol. Sci. Vol.44, No.12, 845-848, 2019
Title: Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells
Author: Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji
J. Toxicol. Sci. Vol.44, No.5, 327-333, 2019
Title: Segment-specific and direction-dependent transport of cadmium and manganese in immortalized S1, S2, and S3 cells derived from mouse kidney proximal tubules
Author: Hitomi Fujishiro, Satoko Hamao, Misaki Isawa, Seiichiro Himeno
J. Toxicol. Sci. Vol.44, No.9, 611-619, 2019

2021

Title: A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers
Author: Ryuji Watari, Motoharu Kakiki, Ayumi Oshikata, Toshiaki Takezawa, Chihiro Yamasaki, Yuji Ishida, Chise Tateno, Yukie Kuroda, Seiichi Ishida, Kazutomi Kusano
J. Toxicol. Sci. Vol.43, No.8, 521-529, 2018
Title: Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats
Author: Yoshimitsu Sakamoto, Motoki Hojo, Yuki Kosugi, Kimiyo Watanabe, Akihiko Hirose, Akiko Inomata, Toshinari Suzuki, Dai Nakae
J. Toxicol. Sci. Vol.43, No.10, 587-600, 2018
Title: Bisphenol AF as an activator of human estrogen receptor β1 (ER β1) in breast cancer cell lines
Author: Hiroyuki Okazaki, Masayo Hirao-Suzuki, Shuso Takeda, Yukimi Takemoto, Ramu Mizunoe, Koichi Haraguchi, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki
J. Toxicol. Sci. Vol.43, No.5, 321-327, 2018
Title: Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat
Author: Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito
J. Toxicol. Sci. Vol.43, No.5, 339-351, 2018
Title: Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells
Author: Tsutomu Takahashi, Saki Suzuki, Suzuka Misawa, Jiro Akimoto, Yo Shinoda, Yasuyuki Fujiwara
J. Toxicol. Sci. Vol.43, No.5, 353-358, 2018
Title: Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism
Author: Tin-Tin Win-Shwe, Nay Chi Nway, Motoki Imai, Thet-Thet Lwin, Ohn Mar, Hidehiro Watanabe
J. Toxicol. Sci. Vol.43, No.11, 631-643, 2018

2020

Title: Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells
Author: Naoya Hirata, Shigeru Yamada, Yuko Sekino, Yasunari Kanda
J. Toxicol. Sci. Vol.42, No.2, 193-204, 2017
Title: Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance
Author: Hiroko Izumi-Nakaseko, Yuji Nakamura, Takeshi Wada, Kentaro Ando, Yasunari Kanda, Yuko Sekino, Atsushi Sugiyama
J. Toxicol. Sci. Vol.42, No.2, 183-192, 2017
Title: Chronotoxicity of bromobenzene-induced hepatic injury in mice
Author: Hiroki Yoshioka, Tsunemasa Nonogaki, Nobuyuki Fukuishi, Yasuro Shinohara, Gi-Wook Hwang, Katsumi Ohtani, Nobuhiko Miura
J. Toxicol. Sci. Vol.42, No.2, 251-258, 2017

2019

Title: Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells
Author: Yang Zeng, Yoshika Kurokawa, Tin-Tin Win-Shwe, Qin Zeng, Seishiro Hirano, Zhenya Zhang, Hideko Sone
J. Toxicol. Sci. Vol.41, No.3, 351-370, 2016
Title: Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate
Author: Hiroki Yoshioka, Haruki Usuda, Tsunemasa Nonogaki, Satomi Onosaka
J. Toxicol. Sci. Vol.41, No.1, 55-63, 2016
Title: Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression
Author: Kanae Umeda, Yaichiro Kotake, Masatsugu Miyara, Keishi Ishida, Seigo Sanoh, Shigeru Ohta
J. Toxicol. Sci. Vol.41, No.2, 255-264, 2016
Title: NF-κB activation via MyD88-dependent Toll-like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol
Author: Kei-ichi Sugiyama, Masashi Muroi, Mawo Kinoshita, Osamu Hamada, Yuji Minai, Yoshiko Sugita-Konishi, Yoichi Kamata, Ken-ichi Tanamoto
J. Toxicol. Sci. Vol.41, No.2, 273-279, 2016

2018

Title: The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules
Author: Kumiko Kohri, Eiko Yoshida, Shuji Yasuike, Tomoya Fujie, Chika Yamamoto, Toshiyuki Kaji
J. Toxicol. Sci. Vol.40, No.3, 321-327, 2015
Title: In silico risk assessment for skin sensitization using artificial neural network analysis
Author: Kyoko Tsujita-Inoue, Tomomi Atobe, Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki
J. Toxicol. Sci. Vol.40, No.2, 193-209, 2015
Title: Chromium (VI)-induced transformation is enhanced by Zn deficiency in BALB/c 3T3 cells
Author: Tomoki Kimura, Akira Onodera, Fumika Okumura, Tsuyoshi Nakanishi, Norio Itoh
J. Toxicol. Sci. Vol.40, No.3, 383-387, 2015
Title: Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST): A novel rapid and highly reproducible in vitro test for embryotoxicity by measuring cytotoxicity and differentiation toxicity using engineered mouse ES cells
Author: Florian Le Coz, Noriyuki Suzuki, Hirohisa Nagahori, Takashi Omori, Koichi Saito
J. Toxicol. Sci. Vol.40, No.2, 251-261, 2015

2017

Title: New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP)
activates central nervous system via dopaminergic neuron
Author: Asuka Kaizaki, Sachiko Tanaka and Satoshi Numazawa
J. Toxicol. Sci. Vol.39, No.1, 1-6, 2014
Title: Involvement of epithelial-mesenchymal transition in methotrexate-induced
pulmonary fibrosis
Author: Masayuki Ohbayashi, Satoshi Kubota, Aya Kawase, Noriko Kohyama, Yasuna Kobayashi and
Toshinori Yamamoto
J. Toxicol. Sci. Vol.39, No.2, 319-330, 2014
Title: Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells
Author: Yuichi Miki, Jiro Akimoto, Michika Hiranuma and Yasuyuki Fujiwara
J. Toxicol. Sci. Vol.39, No.6, 821-827, 2014
Title: FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation
Author: Ke Du, Tsutomu Takahashi, Shusuke Kuge, Akira Naganuma and Gi-Wook Hwang
J. Toxicol. Sci. Vol.39, No.6, 861-866, 2014
Title: Early indicators of delayed adverse effects in female reproductive organs in rats receiving neonatal exposure to 17alpha-ethynylestradiol
Author: Miwa Takahashi, Kaoru Inoue, Tomomi Morikawa, Saori Matsuo, Seigo Hayashi, Kei Tamura,
Gen Watanabe, Kazuyoshi Taya and Midori Yoshida
J. Toxicol. Sci. Vol.39, No.5, 775-784, 2014

2016

Title: Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression
Author: Daisuke Hibi, Aki Kijima, Ken Kuroda, Yuta Suzuki, Yuji Ishii, Meilan Jin, Masahiro Nakajima, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa, Takashi Umemura
J. Toxicol. Sci. Vol.38, No.1, 57-69, 2013
Title: Postnatal exposure to low-dose bisphenol A influences various emotional conditions
Author: Tetsuya Fujimoto, Kazuhiko Kubo, Yasuo Nishikawa, Shuji Aou
J. Toxicol. Sci. Vol.38, No.4, 539-546, 2013
Title: Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin
Author: Kiyonori Kai, Takashi Yamaguchi, Yu Yoshimatsu, Junzo Kinoshita, Munehiro Teranishi, Wataru Takasaki
J. Toxicol. Sci. Vol.38, No.2, 269-277, 2013
Title: Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells
Author: Masanobu Kawanishi, Sayaka Ogo, Miho Ikemoto, Yukari Totsuka, Kousuke Ishino, Keiji Wakabayashi, Takashi Yagi
J. Toxicol. Sci. Vol.38, No.3, 503-511, 2013

2015

Title: Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans
Author: Kozue Yaginuma-Sakurai, Katsuyuki Murata, Miyuki Iwai-Shimada, Kunihiko Nakai, Naoyuki Kurokawa, Nozomi Tatsuta and Hiroshi Satoh
J. Toxicol. Sci. Vol.37, No.1, 123-130, 2012
Title: Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
Author: Atsumi Yamaguchi, Tomoko Fujitani, Ken-ichi Ohyama, Dai Nakae, Akihiko Hirose, Tetsuji Nishimura and Akio Ogata
J. Toxicol. Sci. Vol.37, No.1, 177-189, 2012
Title: Methylglyoxal activates the human transient receptor potential ankyrin 1 channel
Author: Susumu Ohkawara, Toshiko Tanaka-Kagawa, Yoko Furukawa and Hideto Jinno
J. Toxicol. Sci. Vol.37, No.4, 831-835, 2012

2014

Title: Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cells
Author: Tomoyo Hashida, Yaichiro Kotake, Shigeru Ohta
J. Toxicol. Sci. Vol.36, No.1, 1-7, 2011
Title: Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo
Author: Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Satoh
J. Toxicol. Sci. Vol.36, No.2, 191-200, 2011
Title: Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
Author: Gi-Wook Hwang, Jin-Yong Lee, Katsunori Ryoke, Fujio Matsuyama, Jong-Mu Kim, Tsutomu Takahashi, Akira Naganuma
J. Toxicol. Sci. Vol.36, No.3, 389-391, 2011

2013

Title: Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro
Author: Mika Senzui, Toshiaki Tamura, Keiko Miura, Yoshiaki Ikarashi,Yoshiteru Watanabe and Makiko Fujii
J. Toxicol. Sci., Vol. 35, No. 1, 107-113, 2010
Title: Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
Author: Yuta Takahashi, Keisuke Mizuo, Yusuke Shinkai, Shigeru Oshio and Ken Takeda
J. Toxicol. Sci., Vol. 35, No. 5, 749-756, 2010
Title: Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation
Author: Takashi Miura and Yoshito Kumagai
J. Toxicol. Sci., Vol. 35, No. 6, 843-852, 2010

2012

Title: Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
Author: Yoshimitsu Sakamoto, Dai Nakae, Kuniaki Tayama, Akihiko Maekawa, Kiyoshi Imai, Akihiko Hirose, Tetsuji Nishimura and Akio Ogata
J. Toxicol. Sci., Vol. 34, No. 1, PP.65-76 (2009)
Title: Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
Author: Katsunori Yamaura, Eriko Suwa, Hiromi Sato and Koichi Ueno
J. Toxicol. Sci., Vol. 34, No. 4, PP.427-431 (2009)
Title: Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
Author: Joon-Woo Kim, Hiroshi Ishibashi, Yuji Takao, Masashi Hirano, Minoru Koga and Koji Arizono
J. Toxicol. Sci., Vol. 34, No. 2, PP.227-232 (2009)

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